Mechanism of action of anabolic steroids.
Once in the blood, steroid molecules are transported throughout the body, where they react with skeletal muscle cells, sebaceous glands, hair follicles, certain areas of the brain, and certain endocrine glands. Anabolic steroids are fat soluble, so they can penetrate the cell membrane, which is made up of fat; In the cell, anabolic steroids interact (bind) with androgen receptors in the nucleus and cytoplasm. Activated androgen receptors signal to the cell nucleus, causing changes in gene expression or activating processes that send signals to other parts of the cell. As a result, the synthesis of all kinds of nucleic acids is stimulated and the process of forming new protein molecules begins.
AAS are divided into aromatizers (which convert to estrogen), methane, and testosterone esters. Unflavored, Boldenone, Turinabol, Oxandrolone. Dehydrotestosterone derivatives, Masteron, Stanozolol, Primobolan, Proviron. And with progestin activity, trenbolone, deca, oxymethalone.
Drostanolone propionate/enanthate. Masteron.
It is one of the most “exotic” anabolic androgenic steroids. Originally developed as an anti-estrogen called Masteril, the drug was used to treat breast cancer. It has been widely used in the treatment of breast cancer in combination with the SERM (selective estrogen receptor modulator) tamoxifen (or Nolvadex) and has been shown to significantly reduce estrogen levels in women treated with .
Today, for various reasons, it is rarely used for these purposes, however, for many professional athletes and bodybuilders in particular, Masteron remains an almost anonymous favorite among anabolic steroids. Masteron is a derivative of DHT (dihydrotestosterone) and does not convert to estrogen through aromatization. By inhibiting the aromatase enzyme, Masteron prevents the conversion of free testosterone to estrogen through aromatization. This not only serves to slightly increase the amount of active free testosterone in the circulatory system (making testosterone more effective than in a system without the involvement of masteron), but it also negates the side effects which are a consequence of low levels. high estrogen.
These side effects include gynecomastia and fluid retention/edema.
On the other hand, if Masteron blocks the binding of estrogen to estrogen receptors, even if aromatization of testosterone occurs, its effect will be limited due to the inability of estrogen to bind to estrogen receptors. Therefore, through this mechanism, using Masteron, the effect of excessive estrogen production through aromatization will also be limited.
Masteron not only has anti-estrogenic properties but also has anabolic and androgenic qualities.
Although Masteron is not considered a very potent androgen, it actually has a stronger androgenic effect than one would expect. The use of masteron, which is an anabolic androgenic steroid, reduces the natural production of testosterone. Therefore, it should not be thought that Masteron can be used as an alternative in post cycle therapy. Despite the anti-estrogenic effect, it will interfere with recovery.
There are two commonly available forms of Masteron, Drostanolone Propionate and Drostanolone Enanthate. Propionate is typically produced at a dose of 50-150 mg/mL and is a fast-acting version of Masteron that must be taken every other day. Enanthate is usually dosed at a concentration of around 200 mg/mL and requires injections twice a week because the enanthate ester attached to drostanolone works longer with a slow release of the hormone.
Despite the positive properties, Masteron itself is a fairly weak anabolic. It is nearly impossible to get full results using only Masteron. In addition, the use of a masteron can lead to a loss of libido due to a decrease in the production of one’s own testosterone. For this reason, it is recommended to always combine Masteron with testosterone.
Masteron can be safely included in any course that contains testosterone. Dosage at which Masteron should be used:
- 350-500 mg per week (propionate injection every other day)
- 400-600 mg per week (enanthate, injections twice a week)
An example of a great drying course for advanced users (6-10 weeks):
- Testosterone Propionate 150mg every other day
- Trenbolone Acetate 50mg daily (or 100mg every other day)
- Masteron (propionate), 150mg every other day
- Winstrol 50mg daily, last 4 weeks of course only
A drying course more suitable for beginners (6-8 weeks) may consist of:
- Testosterone Propionate 100mg every other day
- Masteron (propionate), 100mg every other day
When using Masteron, the following side effects are possible: hair loss with a tendency to baldness, aggression, prostate problems and acne. If acne has been observed with the use of other androgens such as testosterone, there is a high likelihood that it is occurring due to masteron. There are people who, using testosterone, only a few pimples appeared, and from masteron acne was much stronger.